The basic difference between a hub and a switch is the MAC Table, if we are disabling the mac table for the entire switch, then we are transforming a switch to a hub. which is not a good thing, there is no need to shell thousands of dollars for this need.
So definitely the answer is no mac learning for specific vlan with minimal ports on the vlan and not for the entire switch.
what scenario do we use the no-mac learning, when we need some specifc traffic to flood, ex: taking analyzer outputs on multiple interfaces is one such use of no-mac learning.
-Ramesh.G